LY341495

LY341495

CAT N°: 14693
Price:

From 66.00 56.10

LY341495 is a potent and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC50s = 21 and 14 nM, respectively, for human isoforms).{24137,24136,24138} It less effectively blocks mGluR8 and mGluR7 (IC50s = 173 and 990 nM, respectively) and weakly antagonizes mGluR1, mGluR5, and mGluR4 (IC50s = 6.8, 8.2, and 22 ?M, respectively).{24136} In rat forebrain tissue, LY341495 may bind mGluR3 more avidly than mGluR2.{24135} LY341495 can be effectively used in isolated cells, tissues, and in vivo.{24135,24134,24133} In mice, it penetrates the blood-brain barrier and has been used to study the roles of mGlu2/3 receptors in the brain.{24134,21982,21984}

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