LY2228820 (mesylate)

LY2228820 (mesylate)

CAT N°: 23259
Price:

From 48.00 40.80

LY2228820 is a potent inhibitor of p38? MAP kinase (IC50 = 7 nM for human recombinant p38?).{39389} It inhibits LPS-induced TNF-? production in murine peritoneal macrophages and reduces phosphorylation of MAPKAPK-2 (MK2) in RAW 264.7 cells (IC50s = 5.2 and 34.3 nM, respectively). LY2228820 inhibits TNF-? production in LPS-treated mice and reduces paw swelling and cartilage destruction in a rat model of chronic inflammation with threshold minimum 50% doses (TMED50) values of <1, 1.5, and 1.5 mg/kg, respectively.

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