LY2109761

LY2109761

CAT N°: 15409
Price:

From 66.00 56.10

LY2157299 is a small molecule inhibitor of the TGF-? receptor type 1/type II kinases (IC50 = 69 nM).{25084} It has been used to study the role of TGF-? signaling in tumor cell migration and metastasis in pancreatic tumor cell lines where 5 ?M of the compound completely disrupts Smad-2 phosphorylation, an immediate downstream target of the kinase activity.{25082} It can also suppress radiation-induced inflammatory cytokine signaling and proangiogenic genes, including ID1, in human primary fibrobalsts.{25083}

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