Lupeol

Lupeol

CAT N°: 11215
Price:

From 48.00 40.80

Lupeol, a dietary triterpene found in certain fruits, vegetables, and medicinal plants, has potent anti-inflammatory, anticarcinogenic, antimutagenic, and antimalarial activity. It suppresses the growth of hepatocellular carcinoma cell lines SMMC7721 and HepG2 with IC50 values of 45 and 48.5 ?M and melanoma cell lines Mel 928 and Mel 1241 with IC50 values of 75 and 72 ?M.{20463,20465} At 0.76 g/kg lupeol causes a significant decrease in the blood pressure of stroke-prone hypertensive rats and reduces expression of hepatic genes involved in triglyceride and cholesterol synthesis.{20464} It also has significant anti-inflammatory effects at 50 mg/kg in a carrageenan-induced edema model, inhibiting neutrophil migration.{20466}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (3?)-lup-20(29)-en-3-ol
  • Correlated keywords
    • AC-1371 AC1371 AC 1371 132473-92-8 200123-55-3 fagarsterol dietary triterpenes anti-inflammatory anticarcinogenic antimutagenic antimaralia fruits vegetables medicinal plants antimalarial cells carcinoma cancers SMMC7721 SMMC-7721 SMMC 7721 HepG2 melanoma mel928 mel-928 mel 928 mel1241 mel-1241 mel 1241 blood pressure strokes hypertension rats genes cholesterol synthesis neutrophils monogynol B NSC-90487 NSC90487 beta-viscol b-viscol
  • Product Overview:
    Lupeol, a dietary triterpene found in certain fruits, vegetables, and medicinal plants, has potent anti-inflammatory, anticarcinogenic, antimutagenic, and antimalarial activity. It suppresses the growth of hepatocellular carcinoma cell lines SMMC7721 and HepG2 with IC50 values of 45 and 48.5 ?M and melanoma cell lines Mel 928 and Mel 1241 with IC50 values of 75 and 72 ?M.{20463,20465} At 0.76 g/kg lupeol causes a significant decrease in the blood pressure of stroke-prone hypertensive rats and reduces expression of hepatic genes involved in triglyceride and cholesterol synthesis.{20464} It also has significant anti-inflammatory effects at 50 mg/kg in a carrageenan-induced edema model, inhibiting neutrophil migration.{20466}

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