Loxapine-d<sub>8</sub>

Loxapine-d8

CAT N°: 33537
Price:

From 285.00 242.25

Loxapine-d8 is intended for use as an internal standard for the quantification of loxapine (Item No. 20760) by GC- or LC-MS. Loxapine is an atypical antipsychotic.{24253} It binds to the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 2,456, 7.7, 9.5, 32, and 87.2 nM, respectively), as well as dopamine D2, histamine H1, and M3 muscarinic acetylcholine receptors (Kis = 12, 7, and 122 nM, respectively). Loxapine also binds to ?1A-, ?2A-, ?2B-, and ?2C-adrenergic receptors (Kis = 31, 150.8, 107.6, and 79.9 nM, respectively). Formulations containing loxapine have been used in the treatment of schizophrenia.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-chloro-11-(4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)dibenzo[b,f][1,4]oxazepine
  • Correlated keywords
    • deuterated deuterium GCMS LCMS anti-psychotic 5HT 1A 2A 2C 6 7 5HT1A 5HT2A 5HT2C 5HT6 5HT7
  • Product Overview:
    Loxapine-d8 is intended for use as an internal standard for the quantification of loxapine (Item No. 20760) by GC- or LC-MS. Loxapine is an atypical antipsychotic.{24253} It binds to the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 2,456, 7.7, 9.5, 32, and 87.2 nM, respectively), as well as dopamine D2, histamine H1, and M3 muscarinic acetylcholine receptors (Kis = 12, 7, and 122 nM, respectively). Loxapine also binds to ?1A-, ?2A-, ?2B-, and ?2C-adrenergic receptors (Kis = 31, 150.8, 107.6, and 79.9 nM, respectively). Formulations containing loxapine have been used in the treatment of schizophrenia.

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