Loureirin B

Loureirin B

CAT N°: 27454
Price:

From 72.00 61.20

Loureirin B is a flavonoid originally isolated from D. cochinchinensis, a major component of the traditional herbal medicine dragon’s blood, and has diverse biological activities.{48437,48438,48439} It inhibits Kv1.3-mediated currents, induces membrane depolarization, and reduces calcium influx in Jurkat T cells.{48437} It also inhibits phytohemagglutinin-induced IL-2 release from these cells. Loureirin B (25 ?g/ml) reduces type I collagen and fibronectin protein levels in TGF-?1-stimulated fibroblasts as well as contraction of TGF-?1-stimulated fibroblasts in a gel contraction assay.{48438} It reduces type I collagen and fibronectin protein levels and inhibits phosphorylation of ERK and JNK in isolated human hypertrophic scar tissue. Loureirin B increases glucose absorption and intracellular ATP levels in Ins-1 cells via inhibition of the KATP current and intracellular influx of calcium.{48439}

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