Lobaric Acid

Lobaric Acid

CAT N°: 25205
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From 202.00 171.70

Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites.{42123,42124,42125,42126,42127,42128} It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 ?mol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 ?g/ml).{42124,42125} Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.87 ?M for the human recombinant enzyme) and production of 12(S)-HETE (Item No. 34570) by 12(S)-lipoxygenase (IC50 = 28.5 ?M).{42127,42128} In vivo, lobaric acid (250 ?M) decreases lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV).{42126}

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