LMW-PTP Inhibitor I (hydrochloride)

LMW-PTP Inhibitor I (hydrochloride)

CAT N°: 22277
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From 55.00 46.75

LMW-PTP inhibitor I (hydrochloride) is an inhibitor of low molecular weight phosphotyrosine protein phosphatase A (LMW-PTPA; IC50 = 0.8 µM).{34480} It is selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by greater than 50% at 40 µM. LMW-PTP inhibitor I (hydrochloride) increases insulin-induced insulin receptor phosphorylation in HepG2 cells when used at a concentration of 10 µM. It improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity when administered at a dose of 50 mg/kg per day.

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