LL-37 (trifluoroacetate salt)

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • L-leucyl-L-leucylglycyl-L-?-aspartyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-lysyl-L-seryl-L-lysyl-L-?-glutamyl-L-lysyl-L-isoleucylglycyl-L-lysyl-L-?-glutamyl-L-phenylalanyl-L-lysyl-L-arginyl-L-isoleucyl-L-valyl-L-glutaminyl-L-arginyl-L-isoleucyl-L-lysyl-L-?-aspartyl-L-phenylalanyl-L-leucyl-L-arginyl-L-asparaginyl-L-leucyl-L-valyl-L-prolyl-L-arginyl-L-threonyl-L-?-glutamyl-L-serine, trifluoroacetate salt
• Correlated keywords
  • 436808-85-4 LL37 hCAP18 CAP18 FALL39 chemo-attractant Escherichia Bacillus Mycobacterium Salmonella IL1? TNF? FPRL-1 interleukin DENV2 NS IL6
• Product Overview:
  LL-37 is a cationic and ?-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions.{41499} It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection.{41499,17198,41500} LL-37 binds sheep erythrocytes coated with S. minnesota Re-LPS and induces agglutination with a minimal agglutinating concentration (MAC) of 12.1 ?g/ml.{41501} It is a chemoattractant for, and can induce calcium mobilization in, human monocytes, neutrophils, and T cells that naturally express formyl peptide receptor-like 1 (FPRL1) and FPRL1-transfected HEK293 cells.{41502} LL-37 (10-15 ?M) pretreatment of dengue virus type 2 (DENV-2) reduces its infectivity as well as levels of viral genomic RNA and NS1 antigen.{41503} In vivo, LL-37 inhibits cecal ligation and puncture-induced caspase-1 activation and pyroptosis of peritoneal macrophages, reduces levels of the inflammatory cytokines IL-1?, IL-6, and TNF-?, and improves survival in polybacterial septic mice.{41504}