Lipid A Monophosphoryl from Salmonella minnesota R595

CAT N°: 25848
Price:

675.00 573.75

Lipid A monophosphoryl from Salmonella minnesota R595 is a non-toxic fragment of lipopolysaccharide (LPS) extracted from wild-type S. minnesota R595 and a TRIF biased toll-like receptor 4 (TLR4) agonist.{39965} Lipid A monophosphoryl induces T cell clonal expansion and TRIF-dependent production of G-CSF, IL-10, IP-10, and MCP-1 but has no effect on MyD88-dependent production of the inflammatory cytokines IL-1?, IL-6, MIP-1?, and IFN-? in mice, indicating decreased potential for inflammatory toxicity compared to LPS and use as a non-toxic vaccine adjuvant.

Territorial Availability: Available through Bertin Technologies only in France

  • Correlated keywords
    • 497156-01-1 R-595 WT nontoxic TLR-4 GCSF IL10 IP10 MCP1 MyD-88 IL1? IL6 MIP1? MPLA-SM MPLASM IFN?
  • Product Overview:
    Lipid A monophosphoryl from Salmonella minnesota R595 is a non-toxic fragment of lipopolysaccharide (LPS) extracted from wild-type S. minnesota R595 and a TRIF biased toll-like receptor 4 (TLR4) agonist.{39965} Lipid A monophosphoryl induces T cell clonal expansion and TRIF-dependent production of G-CSF, IL-10, IP-10, and MCP-1 but has no effect on MyD88-dependent production of the inflammatory cytokines IL-1?, IL-6, MIP-1?, and IFN-? in mice, indicating decreased potential for inflammatory toxicity compared to LPS and use as a non-toxic vaccine adjuvant.

We also advise you