Linderane

Linderane

CAT N°: 27479
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66.00 56.10

Linderane is a sesquiterpene that has been found in L. aggregata.{45215,45216} It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 ?M) in an irreversible and NADPH-dependent manner.{45215} Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and CREB phosphorylation, increases phosphodiesterase 3 (PDE3) activity, and inhibits gluconeogenesis in rat primary hepatocytes.{45216} In vivo, linderane (50 mg/kg twice per day) decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice.

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