LH 846

LH 846

CAT N°: 17686
Price:

From 48.00 40.80

LH 846 is a benzothiazole analog that selectively inhibits casein kinase (CK) 1? (IC50 = 290 nM).{32623} It inhibits CK1? and CK1? at much higher concentrations (IC50s = 1.3 and 2.5 ?M, respectively) but does not inhibit CK2.{32623} LH 846 has been shown to inhibit CK1?-dependent phosphorylation and degradation of PER1 protein and to lengthen the circadian period in U2OS cells.{32623}

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