LH 846

LH 846

CAT N°: 17686
Price:

From 48.00 40.80

LH 846 is a benzothiazole analog that selectively inhibits casein kinase (CK) 1? (IC50 = 290 nM).{32623} It inhibits CK1? and CK1? at much higher concentrations (IC50s = 1.3 and 2.5 ?M, respectively) but does not inhibit CK2.{32623} LH 846 has been shown to inhibit CK1?-dependent phosphorylation and degradation of PER1 protein and to lengthen the circadian period in U2OS cells.{32623}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-?(5-?chloro-?6-?methyl-?2-?benzothiazolyl)?-benzeneacetamide
  • Correlated keywords
    • LH846 CK1? CK-1? CK1d 1d U2OS casein benzothiazole CK1? CK1? 1? 1? 1e 1a phosphorylation degradation PER1 PER
  • Product Overview:
    LH 846 is a benzothiazole analog that selectively inhibits casein kinase (CK) 1? (IC50 = 290 nM).{32623} It inhibits CK1? and CK1? at much higher concentrations (IC50s = 1.3 and 2.5 ?M, respectively) but does not inhibit CK2.{32623} LH 846 has been shown to inhibit CK1?-dependent phosphorylation and degradation of PER1 protein and to lengthen the circadian period in U2OS cells.{32623}

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