LG 100754

LG 100754

CAT N°: 19647
Price:

From 48.00 40.80

LG 100754 is a ligand of retinoid X receptor (RXR) that modulates the activity of RXR dimers. It acts as an antagonist towards RXR homodimers but as an agonist of heterodimers consisting of RXR and retinoic acid receptor (RAR) or PPARs.{33119,33120,33121} LG 100754, at 1 µM, is a weak agonist of RXR-PPAR? but strongly enhances signaling through the heterodimer in response to PPAR? ligands, including rosiglitazone (Item No. 71740) and 15-deoxy-?12,14-prostaglandin J2 (Item No. 18570).{33118} Through this action, LG 100754 decreases glucose levels and relieves insulin resistance in mice.{33117,33118}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-2-naphthalenyl)-2E,4E,6Z-octatrienoic acid
  • Correlated keywords
    • 757202-63-4 LG100754 LGD100754 LGN100754 CD-3159 LGD-100754 LGN UVI-2112 PPARg LXRa insulin heterodimer anti-diabetic LBD ligand binding domain LG754 LG-754
  • Product Overview:
    LG 100754 is a ligand of retinoid X receptor (RXR) that modulates the activity of RXR dimers. It acts as an antagonist towards RXR homodimers but as an agonist of heterodimers consisting of RXR and retinoic acid receptor (RAR) or PPARs.{33119,33120,33121} LG 100754, at 1 µM, is a weak agonist of RXR-PPAR? but strongly enhances signaling through the heterodimer in response to PPAR? ligands, including rosiglitazone (Item No. 71740) and 15-deoxy-?12,14-prostaglandin J2 (Item No. 18570).{33118} Through this action, LG 100754 decreases glucose levels and relieves insulin resistance in mice.{33117,33118}

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