Leukotriene E₄ MaxSpec^® Standard

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 5S-hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
• Correlated keywords
  • peptido LTE4 asthma urine uninary allergy SRS-A slow-reacting substance anaphylaxis cysteinyl peptido cys-LTs cysteinyl-leukotriene quantitative standard mass spec spectrometry lipidomics LC-MS
• Product Overview:
  Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4 (Item No. 20310), leaving only the cysteinyl group still attached to the fatty acid backbone.{2236} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).{394} LTE4 is considerably less active (8- to 12-fold) than LTC4 (Item Nos. 20210 | 10007241) in the biological activities characteristic of cysteinyl leukotrienes.{2236,396} Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is most often used as an indicator of asthma.{1815,865,2064} In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.{865} All cysteinyl leukotrienes may contain a small amount of the 11-trans isomer. The purity for all such leukotrienes excludes the 1-4% trans isomer which may be present. LTE4 MaxSpec® standard is a quantitative grade standard of LTE4 (Item No. 20410) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LTE4 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.