Leucinostatin A

Leucinostatin A

CAT N°: 28190
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From 330.00 280.50

Leucinostatin A is a fungal metabolite originally isolated from P. lilacinus with diverse biological activities.{47452} It is active against P. oryzae, B. cinera, P. chrysogenum, X. oryzae, S. cerevisiae, and C. albicans fungi and B. subtilis, S. aureus, S. lutea, and M. phlei bacteria in a disc assay.{47452} Leucinostatin A (0.1-1 ?g/ml) reduces T cell activation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) or an anti-CD3 antibody in a concentration-dependent manner.{47453} It inhibits proliferation of DU145 prostate cancer cells co-cultured with PrSC stromal cells in vitro (IC50 = 0.045 ?g/ml).{47454}

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