LEE011

LEE011

CAT N°: 17666
Price:

From 48.00 40.80

LEE011 is a cyclin-dependent kinase (CDK) inhibitor that targets cyclin D1/CDK4 and cyclin D3/CDK6 at nanomolar concentrations.{28690,28691,28692} It inhibits retinoblastoma protein phosphorylation, which prevents CDK-mediated G1-S phase transition, arresting the cell cycle in the G1 phase, suppressing DNA synthesis, and inhibiting cancer cell growth.{28692} LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC50 = 306 nM in sensitive lines).{28692}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 7-?cyclopentyl-?N,?N-?dimethyl-?2-?[[5-?(1-?piperazinyl)?-?2-?pyridinyl]?amino]?-7H-?pyrrolo[2,?3-?d]?pyrimidine-?6-?carboxamide
  • Correlated keywords
    • 1374639-75-4 1211443-80-9 1374639-79-8 cyclin-dependent kinase inhibitor D1/CDK4 D3/CDK6 cancer biochemical cell cycle inhibit intracellular signaling signal transduction LEE 011
  • Product Overview:
    LEE011 is a cyclin-dependent kinase (CDK) inhibitor that targets cyclin D1/CDK4 and cyclin D3/CDK6 at nanomolar concentrations.{28690,28691,28692} It inhibits retinoblastoma protein phosphorylation, which prevents CDK-mediated G1-S phase transition, arresting the cell cycle in the G1 phase, suppressing DNA synthesis, and inhibiting cancer cell growth.{28692} LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC50 = 306 nM in sensitive lines).{28692}

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