LE300

LE300

CAT N°: 29856
Price:

From 55.00 46.75

LE300 is a dopamine D1-like receptor antagonist (Kis = 1.9 and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively) and antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (pA2 = 8.32 in a rat tail artery assay).{45983,45984} It is selective for dopamine D1 and D5 over D2L and D4.4 receptors (Kis = 44.7 and 109 nM, respectively).{45983} LE300 inhibits the conditioned avoidance response in the pole-jump test in rats (ED50 = 0.94 mg/kg), which is predictive for antipsychotic-like activity.{45985} It also reduces locomotor activity in the open field test in rats (ED50 = 0.74 mg/kg).

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6,7,8,9,14,15-hexahydro-7-methyl-5H-indolo[3,2-f][3]benzazecine
  • Correlated keywords
    • LE 300 D 1 5 2L 4.4 Chinese Hamster Ovary 5HT anti psychotic
  • Product Overview:
    LE300 is a dopamine D1-like receptor antagonist (Kis = 1.9 and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively) and antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (pA2 = 8.32 in a rat tail artery assay).{45983,45984} It is selective for dopamine D1 and D5 over D2L and D4.4 receptors (Kis = 44.7 and 109 nM, respectively).{45983} LE300 inhibits the conditioned avoidance response in the pole-jump test in rats (ED50 = 0.94 mg/kg), which is predictive for antipsychotic-like activity.{45985} It also reduces locomotor activity in the open field test in rats (ED50 = 0.74 mg/kg).

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