LDC-4297

LDC-4297

CAT N°: 23398
Price:

From 55.00 46.75

LDC-4297 is an inhibitor of cyclin-dependent kinase 7 (CDK7; IC50 = 50s = >10, >10, and 1.71 ?M), however, it also inhibits CDK2 and CDK1 (IC50s = 6.4 and 53.7 nM, respectively). LDC-4297 (10-100 nM) induces apoptosis in A549, HeLa, and HCT116 cancer cells in a concentration-dependent manner. It inhibits human cytomegalovirus (HCMV) replication in human fibroblasts (EC50 = 24.5 nM).{43200} LDC-4297 also reduces replication of Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae family viruses (EC50s = 0.02-1.13 ?M).

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 8-(1-methylethyl)-2-(3-piperidinyloxy)-N-[[2-(1H-pyrazol-1-yl)phenyl]methyl]-pyrazolo[1,5-a]-1,3,5-triazin-4-amine
  • Correlated keywords
    • LDC4297 cdk-7 Pyrazolotriazine mRna LDC044297 -044297 A-549 HCT-116
  • Product Overview:
    LDC-4297 is an inhibitor of cyclin-dependent kinase 7 (CDK7; IC50 = 50s = >10, >10, and 1.71 ?M), however, it also inhibits CDK2 and CDK1 (IC50s = 6.4 and 53.7 nM, respectively). LDC-4297 (10-100 nM) induces apoptosis in A549, HeLa, and HCT116 cancer cells in a concentration-dependent manner. It inhibits human cytomegalovirus (HCMV) replication in human fibroblasts (EC50 = 24.5 nM).{43200} LDC-4297 also reduces replication of Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae family viruses (EC50s = 0.02-1.13 ?M).

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