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Latanoprost (free acid)-d4 (Lat-FA-d4) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of Lat-FA by GC- or LC-mass spectrometry. Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.{1107} It is the isopropyl ester of a PGF2? analog containing an aromatic group (17-phenyl) in the ?-chain. As an isopropyl ester, latanoprost acts as a prodrug which is converted to Lat-FA by endogenous esterase enzymes. Lat-FA is a potent FP receptor agonist with an EC50 value of 3.6 nM for human FP receptors, which is twice the potency of PGF2? and more than 200 times more potent latanoprost.{8322} The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid.{3802} However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.{5358}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 100 µg, 50 µg, 500 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 1224443-47-3 |
| Molecular formula | C23H30D4O5 |
| Smiles | O[C@@H]1[C@H](C/C=CC([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](CC[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1, O[C@@H]1[C@H](C/C=CC([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](CC[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1, O[C@@H]1[C@H](C/C=CC([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](CC[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1, O[C@@H]1[C@H](C/C=CC([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](CC[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1 |
| Molecular weight | 394,5 |
| Custom code | 3822.19 |
| Formulation | A solution in methyl acetate |
| Purity | ≥99% deuterated forms (d1-d4) |
| UNSPSC code | 12352100 |
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