β-Lapachone

β-Lapachone

CAT N°: 15021
Price:

108.00 91.80

?-Lapachone is a natural quinone with diverse anti-cancer and anti-inflammatory effects. It inhibits topoisomerase I at 25 ?M and transglutaminase (IC50 = 5 ?M).{22728,22726} In cancer cells which overexpress NAD(P)H:quinone oxidoreductase, ?-lapachone is reduced to ?-lapachone hydroquinone, which generates reactive oxygen species during its reversion to ?-lapachone.{22729} This process sensitizes cancer cells to radiation, suppresses NF-?B activation, and drives apoptosis.{22729,22725,22727}

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