L-Norvaline

L-Norvaline

CAT N°: 34029
Price:

From 48.00 40.80

L-Norvaline is a non-proteinogenic amino acid, an isomer of valine, and an inhibitor of arginase and p70 ribosomal S6 kinase 1 (p70S6K1) kinase.{63018,63019} It inhibits arginase-mediated urea production in J774A.1 macrophage lysates when used at a concentration of 10 mM and TNF-?-induced p70S6K1 activation in human umbilical vein endothelial cells (HUVECs) at 20 mM.{63018} L-Norvaline reduces microgliosis and the level of amyloid-? fibrils in the hippocampus, as well as improves learning and memory in the Morris water maze in the 3xTg mouse model of Alzheimer’s disease.{63020}

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