24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells.{26052,26051} It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells.{26051} Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells.{26051}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 g, 100 mg, 250 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 6491-83-4 |
| Molecular formula | C13H26N2O3 • HCl |
| Smiles | COC([C@@H](NC([C@@H](N)CC(C)C)=O)CC(C)C)=O.Cl |
| Molecular weight | 294,8 |
| Custom code | 2922.19 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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