Ketoconazole

Ketoconazole

CAT N°: 15212
Price:

From 85.00 72.25

Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC50s = 0.031-8 µg/ml).{24649} It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14?-demethylase, which arrests ergosterol (Item No. 19850) biosynthesis at the fungal membrane. Ketoconazole also inhibits human CYP3A4 (IC50 = 0.54 µM). Formulations containing ketoconazole have been used in the treatment of fungal infections.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]-ethanone
  • Correlated keywords
    • 72093-?26-?6 anti-fungals CYPs P-450 CYP-51 3A4 14?-demethylase 14a brizoral fungarest fungoral ketoderm ketoisdin ketozoral nizaral nizoral nizral onofin K orifungal M panfungol phytorol tocon R41400 72093-26-6 ergosterol CYP51A1
  • Product Overview:
    Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC50s = 0.031-8 µg/ml).{24649} It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14?-demethylase, which arrests ergosterol (Item No. 19850) biosynthesis at the fungal membrane. Ketoconazole also inhibits human CYP3A4 (IC50 = 0.54 µM). Formulations containing ketoconazole have been used in the treatment of fungal infections.

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