Kaempferide

Kaempferide

CAT N°: 29673
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102.00 86.70

Kaempferide is a flavonoid that has been found in Alpinia and has diverse biological activities.{46690,46691,46692,46693} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 97.58 ?g/ml).{46690} Kaempferide is cytotoxic to HT-1080 and Colon 26-L5 cells (EC50s = 2.91 and 5.95 ?g/ml, respectively) and decreases lipid accumulation in 3T3-L1 preadipocytes when used at a concentration of 50 ?M.{46691,46692} It attenuates decreases in left ventricular systolic pressure (LVSP) and increases in left ventricular end-diastolic pressure (LVEDP) and reduces infarct size in a rat model of myocardial ischemia-reperfusion injury induced by coronary artery ligation when administered at doses of 0.3 and 1 mg/kg.{46693}

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