K-7174 (hydrochloride)

K-7174 (hydrochloride)

CAT N°: 32773
Price:

From 146.00 124.10

K-7174 is a 20S proteasome inhibitor.{52926} It inhibits the ?1, ?2, and ?5 catalytic subunits of the 20S proteasome when used at a concentration of 5 µM. K-7174 (10 µM) reduces TNF-?- or IL-1?-induced adherence of U937 monocytes to human umbilical vein endothelial cells (HUVECs) in a co-culture model of monocyte-endothelial cell adhesion.{52925} It inhibits tumor growth in U266 and RPMI-8226 multiple myeloma mouse xenograft models when administered at a dose of 75 mg/kg.{52927} K-7174 also inhibits the GATA consensus sequence, reducing TNF-?-induced binding of HUVEC nuclear extracts to GATA motifs in the VCAM1 promoter in an EMSA when used at a concentration of 30 µM.{52924,52925}

We also advise you