JNJ-<wbr/>26854165

JNJ-26854165

CAT N°: 16259
Price:

From 55.00 46.75

The E3 ubiquitin ligase known as murine double minute 2 (MDM2; HDM2 in humans) binds to and then ubiquitinates several proteins, most notably the tumor suppressor p53.{26610,20554} JNJ-26854165 is an antagonist of MDM2 that suppresses the growth of cancer cell lines expressing wild-type p53 (IC50 values range from 240-440 nM).{27796} It induces p53-mediated transcription culminating in apoptotic death of acute leukemia cells.{27796} JNJ-26854165 is orally bioavailable and has anti-proliferative as well as apoptotic actions in various tumor models.{20554} As MDM2 interacts with and modulates several targets in addition to p53, JNJ-26854165 affects multiple signaling pathways.{20554,27795,27797}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N1-[2-(1H-indol-3-yl)ethyl]-N4-4-pyridinyl-1,4-benzenediamine
  • Correlated keywords
    • 881202-16-0 881202-79-5 biochemical inhbitor gene regulation cancer ubiquitin apoptosis MDM2 murine double minute 2 antagonist suppress express expressing wild-type p53 tumor signaling signal biochemical
  • Product Overview:
    The E3 ubiquitin ligase known as murine double minute 2 (MDM2; HDM2 in humans) binds to and then ubiquitinates several proteins, most notably the tumor suppressor p53.{26610,20554} JNJ-26854165 is an antagonist of MDM2 that suppresses the growth of cancer cell lines expressing wild-type p53 (IC50 values range from 240-440 nM).{27796} It induces p53-mediated transcription culminating in apoptotic death of acute leukemia cells.{27796} JNJ-26854165 is orally bioavailable and has anti-proliferative as well as apoptotic actions in various tumor models.{20554} As MDM2 interacts with and modulates several targets in addition to p53, JNJ-26854165 affects multiple signaling pathways.{20554,27795,27797}

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