24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis,{17947} and tumorigenesis.{14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to ?-catenin activation of gene transcription. IWR-1-exo is a diastereomer of IWR-1-endo, the potent inhibitor of the Wnt response.{17505} Whereas IWR-1-endo strongly blocks cell-based Wnt/?-catenin pathway reporter response (IC50 = 180 nM){17505} and suppresses Wnt-dependent zebrafish tail fin regeneration (0.5 ?M),{17948} IWR-1-exo has little effect in either assay at 10 ?M.{17505} Thus, this compound is an ideal control for tests involving the active form, IWR-1-endo.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 25 mg, 5 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 1127442-87-8 |
| Molecular formula | C25H19N3O3 |
| Smiles | [H][C@]12[C@](C(N(C3=CC=C(C(NC4=CC=CC5=C4N=CC=C5)=O)C=C3)C2=O)=O)([H])[C@@H]6C=C[C@H]1C6 |
| Molecular weight | 409,4 |
| Custom code | 2916.31 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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