Isosilybin

Isosilybin

CAT N°: 24913
Price:

365.00 310.25

Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities.{12612,39717,39716} It inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 ?M) and reduces ADP/Fe3+-induced malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release in rat hepatocytes.{12612} Isosilybin inhibits the production of reactive oxygen species (ROS), MDA and LDH release, and reduction in total antioxidant capacity induced by amyloid-? (25-35) (A?25-35) in HT-22 hippocampal cells.{39717} It also increases protein and mRNA expression of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and the aldo-keto reductases (AKCR) 1C1 and AKCR1C2 in HT-22 cells. In vivo, isosilybin (50 and 100 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model.{39716} It also reduces expression of the tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1? in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor-bearing mice.

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