24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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From €109.00 €92.65
Isoscopoletin is a coumarin that has been found in D. fragrans and has diverse biological activities and is an active metabolite of scoparone (Item No. 20046).{63079,63080,63081,63082,63083} It is formed from scoparone by the cytochrome P450 (CYP) isoform Cyp2c29 in mouse liver microsomes.{63083} Isoscopoletin is cytotoxic to A549 lung, MCF-7 breast, and HepG2 liver cancer cells (IC50s = 5.25, 8.58, and 4.76 µM, respectively).{63079} It is active against Gram-positive and Gram-negative bacteria, including S. aureus and E. coli, respectively, as well as the plant pathogenic fungus A. niger, in agar diffusion assays.{63080} Isoscopoletin inhibits 15-lipoxygenase (15-LO; IC50 = 15.1 µM) and reduces paw thickness in a rat model of carrageenan-induced paw edema when administered at a dose of 0.1 mg/kg.{63081,63082}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 776-86-3 |
| Molecular formula | C10H8O4 |
| Smiles | O=C1OC2=C(C=C1)C=C(O)C(OC)=C2 |
| Molecular weight | 192,2 |
| Custom code | 2932.20 |
| Formulation | A solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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