Iso-<wbr/>Olomoucine

Iso-Olomoucine

CAT N°: 13325
Price:

From 82.00 69.70

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression whose function/dysfunction has been implicated in cancer, a subset of human neurodegenerative diseases, and the reward response of addictive drugs via alteration of postsynaptic dopamine receptor signaling. Iso-olomoucine is an inactive stereoisomer of the Cdk5 inhibitor olomoucine. Because iso-olomoucine lacks activity at Cdk5 (IC50 ? 1 mM){15005}, it may have utility as a control compound for determining Cdk5 specificity.{19825,19826,19824} In a Cdk5-independent manner, iso-olomoucine has been shown to rapidly inhibit dopamine transporter activity in rat dorsal striatal synaptosomes with a potency similar to that of olomoucine (IC50 ~37 ?M).{19825}

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