IR 783

IR 783

CAT N°: 31633
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54.00 45.90

IR 783 is a heptamethine cyanine fluorescent probe for in vivo imaging of tumor cells.{54738,54737} It displays excitation/emission maxima of 633/780 nm, respectively. IR 783 is transported into tumor cells, an effect that can be blocked by the organic anion transporting polypeptide (OATP) inhibitor sulfobromophthalein (bromosulfalein; Item No. 21058).{54738} In vivo, IR 783 (11.25 mg/kg) preferentially accumulates in tumor tissue in an ACHN kidney cancer mouse xenograft model.{54737} It has been conjugated to polyethylenimines for tumor-specific gene delivery.{54739}

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