SIRT5 (human, recombinant)
SIRT5 (human, recombinant)
Sirtuin 5 (SIRT5) is an enzyme that catalyzes the NAD-dependent removal of malonyl, succinyl, and glutaryl groups from target proteins.{55107,55108}...
€724.00
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€474.00 €402.90
€474.00 €402.90
The IP Receptor is a class A rhodopsin-like G protein-coupled receptor that mediates the actions of prostaglandin I2 (PGI2).{62350} The C-terminal intracellular tail of the IP receptor undergoes isoprenylation and palmitoylation that results in anchoring of the tail to the plasma membrane. The IP receptor is expressed in platelets and vascular smooth muscle cells and in the aorta, lungs, heart, and kidneys.{62350,3173} It signals through G proteins in a cell type- and expression-dependent manner and is involved in cardiovascular, inflammatory, and immune functions, as well as the pain response.{62350,9805,8508,62351,5018} An arginine-to-cysteine mutation at position 212 in the IP receptor inhibits its ability to activate adenylyl cyclase, which leads to increased platelet aggregation ex vivo and increases disease severity and the incidence of cardiovascular events in patients with a high risk of cardiovascular disease.{62352} The human IP receptor is N-terminally truncated by 28 amino acids compared with the murine receptor.{3173,1614} Cayman’s IP Receptor (human) Polyclonal Antibody can be used for Western blot (WB). The antibody recognizes the IP receptor at approximately 42 kDa from human and mouse samples.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 ea |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Synthetic peptide from the N-terminal region of human IP receptor |
| Application(s) | WB |
| Formulation | 500 µl of peptide affinity-purified antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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