Interleukin-1α (human) ELISA Kit

Territorial Availability: Available through Bertin Technologies only in France

• Correlated keywords
  • enzyme-linked interleukins measures kits eias enzymes immunometrics immunosorbents immunoassays ELISAs IL1? IL-1? IL1.alpha. IL1alpha IL-1.alpha. IL-1alpha interleukin-1alpha interleukin-1.alpha. cytokines assays pro-cytokines enzymatically cleaves cleavages calpain cells types macrophages monocytes astrocytes keratinocytes adipocytes T-cells T eosinophils cell-surfaces surfaces receptors R1 R2 R-1 R-2 RI RII R-I R-II immunity inflammatory inflammations responses mediates mediating mediations host responses infections injury injuries diseases states bowels IBDs shocks atherosclerosis allergy allergies cancers sandwich
• Product Overview:
  Interleukin-1 (IL-1) is a name for a family of proteins which include IL-α, IL-1β, ILra (interleukin receptor antagonist), and IL-18. IL-1α is synthesized as a 33 kDa (271 amino acid) pro-cytokine that is enzymatically cleaved by calpain into the active 159 amino acid, 17 kDa peptide.{10662,10661,10667} IL-1α is produced by many cells types including macrophages, monocytes, astrocytes, keratinocytes, adipocytes, T-cells, and eosinophils.{866} Although IL-1α and IL-1β exhibit only 26% amino acid identity,{10662} they bind to the same cell-surface receptors, IL-1 RI and IL-1 RII, present on a variety of cell types involved in immune or inflammatory responses.{10660,10775,10668} Normal production of IL-1 is critical for mediating host responses to infection and injury.{7221,11054} Disease states in which IL-1 actively participates include inflammatory diseases such as arthritis, inflammatory bowel disease, and shock, as well as atherosclerosis, allergy, and some types of cancer.{7221,11054} Cayman’s IL-1α (human) ELISA Kit is an immunometric (i.e., sandwich) ELISA that permits IL-1α measurements within the range of 3.9-250 pg/ml, typically with a limit of detection of 3.9 pg/ml.