€302.00 €256.70
Inhibin subunit ? A (INHBA) is a member of the TGF-? superfamily with roles in germ cell maturation.{54213,54216} INHBA encodes a 426-amino acid pre-protein, that which is proteolytically cleaved at Gly311 to release the mature INHBA peptide corresponding to amino acids 311-426. Mature INHBA homodimerizes to form activin A, which has roles in the immune response, cell differentiation, and glucose metabolism, and heterodimerizes with INHBB to form inhibin, a complex that negatively regulates gonadal stromal cell proliferation and has tumor suppressor activity. INHBA is overexpressed in various cancers, including breast, lung, esophageal, bladder, and colorectal cancers, and this overexpression is positively correlated with poor prognosis.{54216} Expression of INHBA is increased in granulosa cells isolated from women with polycystic ovaries compared with granulosa cells isolated from women with healthy ovaries.{54215} Germline knockout of Inhba increases skeletal muscle mass in mice.{54214} Cayman’s INHBA (recombinant) protein can be used for cell-based assay applications. This protein consists of 116 amino acids, which correspond to the mature form of human, mouse, and rat, as well as cynomolgus and rhesus monkey, INHBA and has a calculated molecular weight of 13 kDa.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 20 µg, 50 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | |
| Custom code | 3504.00 |
| Formulation | Lyophilized from sterile PBS, pH 7.4 |
| Purity | ≥95% estimated by SDS-PAGE |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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Inositol hexakisphosphate kinase 2 (IP6K2) is a cytoplasmic kinase that catalyzes the conversion of IP6 to diphosphoinositol pentakisphosphate in the...
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Histone H2A is a core histone that forms a dimer with histone H2B.{46631} Two histone H2A/H2B dimers form an octameric...
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