Indomethacin-d<sub>4</sub>

Indomethacin-d4

CAT N°: 25434
Price:

From 136.00 115.60

Indomethacin-d4 is intended for use as an internal standard for the quantification of indomethacin (Item No. 70270) by GC- or LC-MS. Indomethacin is a non-selective COX inhibitor (IC50s = 1.67 and 24.6 µM for human COX-1 and COX-2, respectively).{1286} It reduces filter paper-disc induced growth of granulation tissue, a marker of inflammation, in chick chorioallantoic membranes.{37630} Indomethacin reduces ocular inflammation induced by bovine serum in rabbits.{37631} It also reduces paw edema in a rat model of carrageenan-induced inflammation.{37632}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-(4-chlorobenzoyl-2,3,5,6-d4)-5-methoxy-2-methyl-1H-indole-3-acetic acid
  • Correlated keywords
    • deuterated deuterium LCMS GCMS COX1 COX2 NSC77541, NSC 77541, Indocine, Indometacin, Indometacine, Indonomod
  • Product Overview:
    Indomethacin-d4 is intended for use as an internal standard for the quantification of indomethacin (Item No. 70270) by GC- or LC-MS. Indomethacin is a non-selective COX inhibitor (IC50s = 1.67 and 24.6 µM for human COX-1 and COX-2, respectively).{1286} It reduces filter paper-disc induced growth of granulation tissue, a marker of inflammation, in chick chorioallantoic membranes.{37630} Indomethacin reduces ocular inflammation induced by bovine serum in rabbits.{37631} It also reduces paw edema in a rat model of carrageenan-induced inflammation.{37632}

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