24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Imidazole propionate is a metabolite of histidine.{61341} It is formed from histidine via a urocanate intermediate in gut microbiota by urocanate reductase (urdA). Imidazole propionate (100 µM) decreases protein levels of insulin receptor substrate 1 (IRS-1), IRS-2, and phosphorylated Akt and increases levels of the mTORC1 activation marker phosphorylated p70 ribosomal S6 kinase (p70S6K) in primary mouse hepatocytes. It induces deficits in glucose tolerance in germ-free and conventionally raised mice when administered at doses of 500 and 100 µg/animal, respectively. It also prevents reductions in blood glucose levels induced by metformin (Item No. 13118) in mice.{61342} Plasma levels of imidazole propionate are increased in patients with type 2 diabetes.{61341,61342}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 g, 100 mg, 250 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 1074-59-5 |
| Molecular formula | C6H8N2O2 |
| Smiles | O=C(CCC1=CN=CN1)O |
| Molecular weight | 140,1 |
| Custom code | 2933.29 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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