Ilimaquinone

Ilimaquinone

CAT N°: 15124
Price:

337.00 286.45

Ilimaquinone is a natural sesquiterpene quinone that has antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties.{24002} In mammalian cells, 25 µM ilimaquinone reversibly induces vesiculation of Golgi membranes, blocking the secretory pathway.{24001,24000} It inhibits the conversion of S-adenosylhomocysteine (SAH) to homocysteine by SAH hydrolase (IC50 = 40 µM).{24002,24003} Ilimaquinone also inhibits DNA polymerase ? and dual specificity phosphatase Cdc25B (IC50 = 45.2 and 92 µM, respectively) and, at 10 µM, activates gene expression through hypoxia-inducible factor-1.{24006,24004}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-[[(1R,2S,4aS,8aS)-decahydro-1,2,4a-trimethyl-5-methylene-1-naphthalenyl]methyl]-2-hydroxy-5-methoxy-2,5-cyclohexadiene-1,4-dione
  • Correlated keywords
    • 820243-60-5 natural products inhibitors inhibits inhibitions hypoxia antivirals antibiotics inflammation sesquiterpene quinones antimicrobials anti-microbial microbials anti anti-HIV antiHIV HIV anti-mitotic mitotic antimitotic anti-inflammatory inflammatory antiinflammatory golgi members anti-virals virals SAHs S-adenosylhomocysteine DNA Cdc25B ilimaquinone mammalian cells reversibly induces vesiculation membranes blocking blocks secretory pathways conversions S adenosylhomocysteine homocysteine hydrolases polymerases ? B beta .beta. phosphatases genes expressions hypoxia-inducible factor-1 inducible factor 1
  • Product Overview:
    Ilimaquinone is a natural sesquiterpene quinone that has antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties.{24002} In mammalian cells, 25 µM ilimaquinone reversibly induces vesiculation of Golgi membranes, blocking the secretory pathway.{24001,24000} It inhibits the conversion of S-adenosylhomocysteine (SAH) to homocysteine by SAH hydrolase (IC50 = 40 µM).{24002,24003} Ilimaquinone also inhibits DNA polymerase ? and dual specificity phosphatase Cdc25B (IC50 = 45.2 and 92 µM, respectively) and, at 10 µM, activates gene expression through hypoxia-inducible factor-1.{24006,24004}

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