IL-1R Antagonist

IL-1R Antagonist

CAT N°: 21349
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From 51.00 43.35

IL-1R antagonist is a peptide mimic of the myeloid differentiation primary response gene 88 (MyD88) that changes the interaction of MyD88 and IL-1 receptor type I (IL-1RI).{39170} In mouse lymphocytes and thymoma EL4 cells, IL-1R antagonist (?10 ?M) inhibits IL-1?-activated phosphorylation of p38 MAP kinase, a process specifically mediated by disruption of IL-1RI/MyD88. However, it has no influence on LPS-mediated TLR4/MyD88 signaling in freshly isolated mouse lymphocytes (100 ?M). IL-1R antagonist also attenuates IL-1?-induced fever (200 mg/kg) and Staphylococcal enterotoxin B (SEB)-induced pro-inflammatory cytokine production and toxicity in mice at doses between 2-6 mg.{39170, 39171}

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