IKK2 Inhibitor VI

IKK2 Inhibitor VI

CAT N°: 17276
Price:

From 94.00 79.90

Inhibitor of NF-?B kinase 2 (IKK2, also known as IKK?) acts as part of an IKK complex in the canonical NF-?B pathway, phosphorylating inhibitors of NF-?B (I?Bs) to initiate signaling. NF-?B signaling can also occur through a non-canonical, IKK/I?B-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM).{17345} It is used to evaluate the role of the canonical, I?B-dependent NF-?B signaling pathway in cellular responses.{28299,28300}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-[(aminocarbonyl)amino]-5-phenyl-3-thiophenecarboxamide
  • Correlated keywords
    • biochemical inhibitor signal transduction intracellular signaling NF-kB inflammation inhibit NF-?B NF?B IKK-2 IKK? kinase 2 IKK complex canonical pathway phosphorylation I?B potent cell-permeable reversible I?B-dependent cellular response CHR5805 CHR 5805 (5-phenyl-2-ureido)thiophene-3-carboxamide 5-phenyl-2-ureido
  • Product Overview:
    Inhibitor of NF-?B kinase 2 (IKK2, also known as IKK?) acts as part of an IKK complex in the canonical NF-?B pathway, phosphorylating inhibitors of NF-?B (I?Bs) to initiate signaling. NF-?B signaling can also occur through a non-canonical, IKK/I?B-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM).{17345} It is used to evaluate the role of the canonical, I?B-dependent NF-?B signaling pathway in cellular responses.{28299,28300}

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