€617.00 €524.45
Immunoglobulin M (IgM) is a member of the immunoglobulin superfamily of glycoproteins that plays a central role in the adaptive immune response and in mucosal immunology.{28520,53830} IgM consists of two light chains of approximately 25 kDa each, as well as two heavy chains of approximately 70 kDa each that contain C-terminal extensions, known as tailpieces, which allow for IgM oligomerization.{53830,53831} The heavy chains are linked together by disulfide bonds to form an Fc region and also combine with the light chains to form the Fab region, which mediate receptor and antigen binding, respectively.{55171} Five IgM proteins oligomerize via disulfide bonds in the presence of a 15-kDa joining chain, a process that is required for transcytosis of IgM from plasma cells to mucosal epithelial cells via the polyimmunoglobulin receptor (pIgR).{53830} Monomeric and oligomeric IgM are both ligands for the IgM and IgA-binding high affinity Ig? and the Ig? Fc receptor (Fc?/?-R) on dendritic cells, which mediates cellular uptake of IgM-conjugated antigens, and the IgM-binding Fc?-R on B and T cells, which is important for B cell maturation among other functions.{53830,53832,53833,53834} IgM is produced primarily in the plasma by naïve B cells and expressed in its monomeric low-affinity form on the cell surface.{28520} Activated B cells secrete pentameric high-affinity IgM, which opsonizes antigens to target them for removal by phagocytes and to activate complement via the classical pathway.{28520,53835} IgM antibodies are produced early in infection and have been used to determine exposure to a specific pathogen.{28520} IgM levels are elevated in hyper-IgM syndromes, which are characterized by dysfunctions in Ig class switching recombination.{53836} Cayman’s IgM (mouse) Rabbit Monoclonal Antibody – Biotinylated can be used for ELISA.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 50 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Mouse IgM |
| Clone | RM109 |
| Isotype | IgG |
| Application(s) | ELISA |
| Formulation | 50 µg of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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