ICI 63197

ICI 63197

CAT N°: 35538
Price:

From 151.00 128.35

ICI 63197 is an inhibitor of phosphodiesterase 3 (PDE3) and PDE4 (Kis = 9 and 10 µM, respectively).{68051} It is selective for PDE3 and PDE4 over PDE1 and PDE2 (Kis = 487 and >1,000 µM, respectively). ICI 63197 inhibits acetylcholine-induced bronchospasm in isolated guinea pig lungs and histamine-induced bronchospasm in conscious guinea pigs.{68052} It decreases motor activity and rectal temperature and induces forepaw shaking, head twitches, and grooming in rats in a dose-dependent manner.{68053}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
  • Correlated keywords
    • 33406-42-7 ICI63197 PDE 1 2 3 4 bronch spasm
  • Product Overview:
    ICI 63197 is an inhibitor of phosphodiesterase 3 (PDE3) and PDE4 (Kis = 9 and 10 µM, respectively).{68051} It is selective for PDE3 and PDE4 over PDE1 and PDE2 (Kis = 487 and >1,000 µM, respectively). ICI 63197 inhibits acetylcholine-induced bronchospasm in isolated guinea pig lungs and histamine-induced bronchospasm in conscious guinea pigs.{68052} It decreases motor activity and rectal temperature and induces forepaw shaking, head twitches, and grooming in rats in a dose-dependent manner.{68053}

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