IACS-010759

IACS-010759

CAT N°: 25867
Price:

From 68.00 57.80

IACS-010759 is an orally bioavailable inhibitor of complex I of the mitochondrial electron transport chain.{42644,42645} It inhibits the ubiquinone reduction activity of isolated murine mitochondrial complex I when used at a concentration of 60 nM.{42644} IACS-010759 (100 nM) reduces basal and spare respiratory capacities and increases glycolytic flux in primary chronic lymphocytic leukemia (CLL) cells.{42645} It also induces apoptosis in CLL cells grown under low glucose conditions or when administered in combination with 2-deoxy-D-glucose (Item No. 14325). IACS-010759 (5 and 10 mg/ml) induces tumor regression in a glycolysis-deficient NB1 mouse xenograft model.{42644}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-(methylsulfonyl)-1-[3-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-1,2,4-triazol-1-yl]methyl]phenyl]-piperidine
  • Correlated keywords
    • IACS10759 10759 NB-1 OxPhos Ox-Phos
  • Product Overview:
    IACS-010759 is an orally bioavailable inhibitor of complex I of the mitochondrial electron transport chain.{42644,42645} It inhibits the ubiquinone reduction activity of isolated murine mitochondrial complex I when used at a concentration of 60 nM.{42644} IACS-010759 (100 nM) reduces basal and spare respiratory capacities and increases glycolytic flux in primary chronic lymphocytic leukemia (CLL) cells.{42645} It also induces apoptosis in CLL cells grown under low glucose conditions or when administered in combination with 2-deoxy-D-glucose (Item No. 14325). IACS-010759 (5 and 10 mg/ml) induces tumor regression in a glycolysis-deficient NB1 mouse xenograft model.{42644}

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