€337.00 €286.45
Histone H1 is a nuclear protein that interacts with linker DNA regions between nucleosomes to provide nucleosome core structure stabilization.{60991,52742} Histone H1 subtypes are comprised of a short N-terminal domain, a central globular domain necessary for DNA interaction, and long C-terminal domain that determines subtype binding properties by its variability.{52742} Histones H1.1-H1.5 are expressed in somatic cells in a replication-dependent manner, and cell-type specificity varies based on histone H1 subtype.{60992} Histone H1 is involved in chromatin organization, gene expression, protection of DNA from digestion by micrococcal nuclease, the DNA damage response, and cell differentiation.{52742,60993} Knockdown of H1-2 and H1-4 decreases proliferation of T47D breast cancer cells, and H1-2 knockdown also induces cell cycle arrest at the G1 phase in the same cells.{52745} Histone H1 is highly post-translationally modified, including phosphorylation, acetylation, citrullination, ubiquitination, and methylation.{60993} Phosphorylation of histone H1 at Thr146 is associated with increasing breast cancer tumor grade.{60994} Cayman’s Histone H1 (bovine) protein can be used as a substrate for enzyme activity assays, as well as for Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 25 mg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | A solution in water (frozen) |
| Purity | ≥80% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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