Hexamethonium (bromide)

Hexamethonium (bromide)

CAT N°: 25505
Price:

From 37.00 31.45

Hexamethonium is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as an antagonist of nicotinic acetylcholine receptors (nAChRs).{46022,46021} It decreases acetylcholine release induced by carbamoylcholine (Item No. 14486) in isolated cat superior cervical ganglion when used at concentrations of 27.4 and 54.8 µg/ml.{46023} It also decreases mean arterial pressure in unanesthetized rats when administered at a dose of 40 mg/kg.{46024} Intraventricular administration of hexamethonium (18 ng, i.c.v.) induces signs of nicotine abstinence, including shaking, writhing, and chewing in nicotine-dependent rats.{46025} Formulations containing hexamethonium were previously used in the treatment of hypertension.

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