Histone H2A (Xenopus, recombinant)
Histone H2A (Xenopus, recombinant)
Histone H2A is a core histone that forms a dimer with histone H2B.{46631} Two histone H2A/H2B dimers form an octameric...
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€615.00 €522.75
€615.00 €522.75
Helicobacter pylori (H. pylori) is a Gram-negative bacterium that can infect and colonize the stomach, leading to chronic gastritis, stomach inflammation and oxidative stress, peptic ulcer disease, and gastric cancer.{54750} H. pylori neutrophil-activating protein (HP-NAP) is a virulence factor and member of the DNA-protecting proteins from starved cells (Dps) family.{54751} It is composed of 12 identical monomers each containing four ?-helices.{54752} It activates neutrophils and increases their infiltration into the gastric mucosa by increasing the production of reactive oxygen species (ROS), secretion of myeloperoxidase (MPO), and release of cytokines from a variety of host immune cells.{54751} HP-NAP protects H. pylori from bacterial DNA damage induced by this oxidative stress. It also induces a cytotoxic Th1 response in T cells in vitro and is a toll-like receptor 2 (TLR2) agonist that activates NF-?B in HEK293 cells.{54753} HP-NAP is an iron-binding protein, and H. pylori strains isolated from patients with iron-deficiency anemia have a SNP in napA, the gene encoding HP-NAP, and an increase in iron uptake compared with strains not containing the SNP.{54752,54754} HP-NAP is immunogenic in humans, and oral recombinant HP-NAP administration is protective against H. pylori infection in mice.{54755} Cayman’s Helicobacter pylori NAP Rabbit Monoclonal Antibody (Clone RM414) can be used for ELISA.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Proteins purified from H. pylori |
| Clone | RM414 |
| Isotype | IgG |
| Application(s) | ELISA |
| Formulation | 100 µg of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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