Helenalin

Helenalin

CAT N°: 17050
Price:

761.00 646.85

Helenalin is a sesquiterpene lactone first isolated from various species of Arnica. It has anti-inflammatory effects, most notably by inhibiting gene expression mediated by NF-?B at doses from 1 to 20 µM.{27838,24738} Like other sesquiterpene lactones, helenalin can modify sulfhydryl groups of cysteine residues and it alkylates these groups on the p65 subunit of NF-?B.{27838} It also suppresses the proliferation of cancer cells through multiple mechanisms, including the prevention of signaling through NF-?B.{27836,20972,27837} Helenalin has antibacterial and anti-protozoal activities.{27839,27840}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3,3aS,4S,4aR,7aR,8R,9,9aR-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-azuleno[6,5-b]furan-2,5-dione
  • Correlated keywords
    • biochemical natural product inflammation NF-?B inhibitor intracellular signaling cancer antibiotic signal transduction anti-inflammatory sesquiterpene lactone Arnica species inhibit gene expression mediate modify sulfhydryl group cysteine residue alkylate p65 subunit suppress proliferation cell mechanism prevent antibacterial anti-protozoal protozoan activity (-)-Helenalin A
  • Product Overview:
    Helenalin is a sesquiterpene lactone first isolated from various species of Arnica. It has anti-inflammatory effects, most notably by inhibiting gene expression mediated by NF-?B at doses from 1 to 20 µM.{27838,24738} Like other sesquiterpene lactones, helenalin can modify sulfhydryl groups of cysteine residues and it alkylates these groups on the p65 subunit of NF-?B.{27838} It also suppresses the proliferation of cancer cells through multiple mechanisms, including the prevention of signaling through NF-?B.{27836,20972,27837} Helenalin has antibacterial and anti-protozoal activities.{27839,27840}

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