24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Hederacoside C is a saponin that has been found in K. pictus and has anti-inflammatory activity.{36806,36808} It is an inhibitor of acetylcholinesterase (AChE; IC50 = 31.3 ?M).{36808} Hederacoside C (0.5-5 ?g) inhibits mutagenicity induced by aflatoxin B1 (Item No. 11293) in S. typhimurium agar cultures from 21 to 67%.{36807} It reduces TNF-?, IL-1?, IL-6, COX-2, and nitric oxide synthase (NOS) levels in a concentration-dependent manner and IL-1 receptor-associated kinase-1 (IRAK1) activity in isolated mouse peritoneal macrophages stimulated by LPS when used at concentrations ranging from 5 to 10 ?M.{36806} Hederacoside C (0.02 mg/kg) reduces carrageenan-induced hind paw edema by 37% compared to vehicle control in a rat model of acute inflammation.{36809} It reduces scopolamine-induced memory impairment and increases latency in a passive avoidance test and spontaneous alteration in a Y-maze in mice by 100 and 59%, respectively, when administered at a dose of 40 mg/kg.{36808} Hederacoside C (5 mg/kg, i.p.) reduces serum levels of TNF-? and IL-1? in LPS-challenged mice by 60 and 65%, respectively.{36806}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 100 mg, 25 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 14216-03-6 |
| Molecular formula | C59H96O26 |
| Smiles | CC1(C)CC[C@]2(C(O[C@@H]3O[C@H](CO[C@H]4[C@H](O)[C@@H](O)[C@H](O[C@@]5([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](CO)O4)[C@@H](O)[C@H](O)[C@H]3O)=O)CC[C@@]6(C)[C@]7(C)CC[C@@]8([H])[C@@](CO)(C)[C@@H](O[C@]9([H])OC[C@H](O)[C@H](O)[C@H]9O[C@@]([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O)CC[C@]8(C)[C@@]7([H])CC=C6[C@]2([H])C1 |
| Molecular weight | 1221,4 |
| Custom code | 2932.99 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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