Hecogenin

Hecogenin

CAT N°: 21372
Price:

66.00 56.10

Hecogenin is a natural steroid sapogenin with diverse biological activities that was originally isolated from A. sisalana and has been used in the synthesis of steroids.{38813} It has antioxidant, anti-inflammatory, antiproliferative, and neuroprotective properties.{38814,38815,38816,38817} Hecogenin (10 ?M) decreases superoxide anion formation induced by N-Formyl-Met-Leu-Phe (fMLP; Item No. 21495) in rat neutrophils by 23.6%.{38814} It also inhibits myeloperoxidase (MPO) release from human neutrophils activated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) when used at a concentration of 1 ?g/ml.{38815} Hecogenin inhibits proliferation of the breast cancer cell lines MDA-MB-231, MDA-MB-468, MCF-10A, MCF-7, T47D, BT474, and SK-BR-3 (IC50s = 28.7-38.2 ?M).{38816} It decreases the number of glutamate-induced TUNEL-positive primary rat spinal motor neurons by 11% when used at a concentration of 1 ?M.{38817} In vivo, hecogenin (15 mg/kg) decreases the mucosal lesion area of ethanol-induced gastric ulceration in mice.{38815} It also decreases tumor volume in an MDA-MB-231 human breast cancer mouse xenograft model when administered at a dose of 10 mg/kg three times per week.{38816}

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