Heclin

Heclin

CAT N°: 26139
Price:

48.00 40.80

Heclin is an inhibitor of HECT E3 ubiquitin ligases (IC50s = 6.8, 6.3, and 6.9 ?M for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively).{43931} It inhibits autoubiquitination of Smurf2 in HEK293 cells expressing the human enzyme (IC50 = 9 ?M) and reduces ubiquitination of Dishevelled 2 in HEK293 cells expressing Smurf2, Nedd4, or WWP2. Heclin is cytotoxic to HEK293 cells (IC50 = 45 ?M).

We also advise you