Harringtonine

Harringtonine

CAT N°: 15361
Price:

From 66.00 56.10

Harringtonine is a natural alkaloid that inhibits protein synthesis at low micromolar concentrations.{25658} It immobilizes ribosomes immediately after the initiation of translation.{25658,25659} While harringtonine has drawn some interest in mitigating cancer, its homolog homoharrington is more effective, particularly for chronic myelogenous leukemia.{25660,25662,25661} The ability of harringtonine to immobilize initiating ribosomes can be used to capture ribosome-protected mRNA fragments for evaluating translation.{25659}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-[4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate]cephalotaxine
  • Correlated keywords
    • 25302-?09-?4 88455-?80-?5 natural products inhibitors cancers inhibits inhibitions alkaloids proteins synthesis homoharrington ribosomes translations NSCs 124147 NSC124147 NSC-124147 harringonin immobilizes initiations homologs chronic myelogenous leukemia ribosome-protected protected mRNA m fragments
  • Product Overview:
    Harringtonine is a natural alkaloid that inhibits protein synthesis at low micromolar concentrations.{25658} It immobilizes ribosomes immediately after the initiation of translation.{25658,25659} While harringtonine has drawn some interest in mitigating cancer, its homolog homoharrington is more effective, particularly for chronic myelogenous leukemia.{25660,25662,25661} The ability of harringtonine to immobilize initiating ribosomes can be used to capture ribosome-protected mRNA fragments for evaluating translation.{25659}

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